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Indications for a direct connection between the nose and the CNS were discovered at the beginning of the last century [8], as researchers were able to show that substances injected into the subarachnoid space can reach the nasal mucosa [21]

The FDA warns that individuals who take multiple over-the-counter medications containing acetaminophen, such as cold and flu medicines, unknowingly surpass the overdose threshold, putting themselves at risk of serious harm

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Animal studies show minimal toxicity at therapeutic doses over 11 days, with no observed hepatotoxicity, nephrotoxicity, or CNS effects

To D., Steinbring C., Weber L

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