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Oxidative stress is represented in the model by the concentration of H 2 O 2

Thus, PXR facilitates the metabolism and elimination of xenobiotics, including drugs, with notable consequences

4.5 Diabetic neuropathy GLPs exhibit broad-spectrum neuroprotective properties across a range of neurological disorderssuch as Alzheimers disease (AD), spinal cord injury (SCI), cerebral ischemia, epilepsy, major depressive disorder, and neuroinflammatory conditions

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237 Notably, some studies suggest that ROS-mediated inhibition of the PI3K pathway regulates cell death and enhances chemotherapy sensitivity in cancers, although the exact mechanisms are unclear 238,239 (Table 1, Fig