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Anais Brasileiros Dermatologia 88, 7683

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Cell culture studies demonstrate increased expression of synaptic proteins including PSD-95, synaptophysin, and synapsin following Dihexa treatment, confirming molecular mechanisms underlying the observed synaptogenic effects

10.1016/j.ejpb.2024.114513 239

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It is activated mainly through the RIPK1/RIPK3/MLKL signaling axis, which features plasma membrane rupture and release of pro-inflammatory cytokines