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7.4 Synergistic intervention 7.4.1 Combination of Nrf2 activators and A clearance Nrf2 activators centered on sulforaphane are driving a paradigm shift in AD treatment from traditional single-pathway approaches toward a dual-track strategy targeting both pathological clearance and ferroptosis blockade

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423 Furthermore, the study emphasized that neurons in specific brain regions, such as the hindbrain and hypothalamus, co-express GLP-1R along with 1-adrenergic and -opioid receptors, suggesting a localized mechanism within the CNS that could coordinate peripheral anti-inflammatory responses

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