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This uncertainty is recognised in laboratory medicine guidance from bodies such as the Association for Clinical Biochemistry and Laboratory Medicine (ACB) and the Royal College of Pathologists (RCPath)

10.1080/15548627.2020.1752548 13 DilekN.PapapetropoulosA.Toliver-KinskyT.SzaboC

Formulation Factors The osmolality of nasal formulations is a crucial factor, since hypertonic and hypotonic formulations can disrupt normal cilial movement, leading to reduced nasal drug absorption