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Both conditions involve complex pathological mechanisms that include primary mechanical damage followed by secondary injury cascades involving inflammation, oxidative stress, and regulated cell death pathways such as ferroptosis (217, 218)

Which injection sites are used for NAD+

Reduced hepatic bilirubin clearance can be due to defective (i) unconjugated bilirubin uptake and intrahepatic storage, (ii) conjugation of glucuronic acid to bilirubin (e.g., Gilbert syndrome, CriglerNajjar syndrome, LuceyDriscoll syndrome, breast milk jaundice), (iii) bilirubin excretion into bile (DubinJohnson syndrome), or (iv) conjugated bilirubin re-uptake (Rotor syndrome)

doi: 10.1038/s41420-022-01205-z

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This approach is not widely used in adults, due to the high incidence of GVHD, transplant-related mortality and GR, but it may be used to treat children with class I/II -thalassemia safely, provided that ATG is given [100]