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The alternative efflux substrate of ASCT2, Serine can derive from glucose via a three enzymes pathway, i.e., phosphoglycerate dehydrogenase, phosphoserine aminotransferase, and phosphoserine phosphatase (resumed by the dotted arrow of Figure 1B)

1999b;31:S121127

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Here we report that the SLC7A11/glutathione axis displays metabolic synthetic lethality with oncogenic KRAS

The comprehensive understanding of the underlying mechanisms now sheds light on why this protection extends across a broad spectrum of chronic conditions, encompassing both neurodevelopmental and neurodegenerative origins

Ergothioneine oxidation in the protection against high-glucose induced endothelial senescence: Involvement of SIRT1 and SIRT6