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Metabolic studies with acetylcysteine

Subsequently, they conducted in vivo experiments to validate the tumor-suppressive role of MIEAP and found that the concurrent knockout of MIEAP and autophagy-related gene 5 (ATG5) accelerated TC development and induced the oncocytic phenotype in BRAF V600E -positive thyroid cells [169]

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doi: 10.1016/j.trac.2021.116423 42 CaoW.MatharooG

PLP is required for the synthesis of heme via the enzyme catalyzing the initial and regulated step in this pathway, -aminolevulinic acid synthase (ALAS)

Biochim Biophys Acta Mol Cell Biol Lipids 1863:10951107