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Biomaterials 265:120448

Glutathione acts as a cofactor and antioxidant, stabilizing TPO activity and reducing hydrogen peroxide-induced enzyme damage

Caffeine, too, can raise cortisol levels and cause oxidative stress, meaning more glutathione is needed to combat it

This helps promote natural repair, calm inflammation, and support immune and respiratory health from the inside out

In TGR, and more generally in TrxRs, electron transfer from NADPH to the enzyme is fast and practically irreversible and so an actual ES complex (NADPH-TGR) is not significantly populated during the catalytic cycle 17

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