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[19] The enzymes that use B 12 as a built-in cofactor are methylmalonyl-CoA mutase (PDB 4REQ [43] ) and methionine synthase (PDB 1Q8J)

The logic is synergistic: provide the raw material (NR/NMN) while simultaneously blocking the leak (5-Amino-1MQ) to maximize cellular NAD+ levels

For some groups, the numbers are even more concerning up to 90% of vegans and vegetarians may be deficient without proper supplementation

Compounded medications are not reviewed or approved by the FDA

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