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Patel: Thats what Im doing

It has been shown that GSTT1 expression is significantly upregulated in chemotherapy-resistant serous ovarian cancer (SOC) cells and that inhibition of GSTT1 expression negatively influenced the proliferation of SOC cells, thereby enhancing their sensitivity to paclitaxel/carboplatin [116]

Once reconstituted , degradation accelerates significantly

There is no clinical trial data specifically studying this approach, but some prescribers report anecdotally that patients maintain better long-term responses with periodic dose reductions

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