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[139], exists that raises concerns about the role of sterile inflammation and the importance of inflammasome activation during APAP hepatotoxicity, and the majority of experimental evidence suggests that the extensive sterile inflammatory response during APAP hepatotoxicity is mainly beneficial by limiting the formation and the impact of pro-inflammatory mediators and by promoting tissue repair [143]

That means that theres no maximum daily dose thats known to cause adverse effects to the general population

When evaluating adipose tissue in WT and 3-KO mice, researchers found that neither treatment significantly affected white adipose tissue mass in either genotype

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Bioavailability is essential