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b P -value for comparison between erdosteine and placebo group from Wilcoxon rank-sum test (exacerbation rate) or log rank test (time to first exacerbation) or Mann-Whitney U-test (duration of exacerbation)

Thus, rapid ROS accumulation is being observed under hypoxic conditions resulting from mitochondrial disfunction and a decrease of intracellular pH

in terms of safety, tolerability and immunogenicity

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Synthesis and Characterization of Diketopiperazine Derived From AX Sodium AX (19 mg, 0.05 mmol) and DTT (15 mg, 0.1 mmol) were dissolved in 1.5 ml of degassed H 2 O under N 2 atmosphere and stirred overnight at room temperature

Since the cell membrane is constructed of PLs, DHA is usually esterified to phosphatidylcholine (PC) or phosphatidylethanolamine (PE) at the sn-2 position, which significantly increases the absorption of DHA and EPA in KO (52, 61, 62)