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In a double-blind randomized controlled trial of 46 bipolar disorder patients, N-acetylcysteine (2000 mg/d) treatment for 6 months did not result in any significant differences in cognitive measures including digit span, word learning, trail making, and verbal fluency when compared with the placebo group (15)

USF1 and USF2, but not c-Myc, can bind to this E-box and overexpression of either one can inhibit the promoter activity (Cheng et al., 2005)

Furthermore, high-throughput omics techniquesincluding genomics, proteomics, and metabolomicscombined with bioinformatics offer powerful tools for systematically investigating the molecular mechanisms underlying toxicity (Martinez-Sena et al., 2023)

In mammals, ascorbate is synthesised in the liver but, presumably because it is not made by humans, details of pathway control have received very little attention since the 1960s

Basile LA, Taylor SN, Wagner CL, Horst RL, Hollis BW

Within the lung epithelial tissue, alveolar epithelial type I (AT1) cells are the primary mediators of gas exchange, occupying most of the epithelial surface