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10.1080/13880209.2021.1974059 236 YuB.JinL.YaoX.ZhangY.ZhangG.WangF.et al (2023)
Microglial homeostasis requires balanced CSF-1/CSF-2 receptor signaling

Nutrient Deficiencies (Building Blocks Missing) Glutathione synthesis requires specific nutrients: Cysteine : From dietary protein (whey, eggs, poultry)-rate-limiting Glycine : Often deficient in modern diets (need 10-15g/day, most get 3-5g) Selenium : Cofactor for glutathione peroxidase (GPx) , the enzyme that recycles GSSG back to GSH B vitamins (B6, B9, B12): Required for methylation and sulfur metabolism Vitamin C : Recycles oxidized glutathione Deficiency in any of these impairs glutathione production or recycling [5]

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This misalignment is frequently influenced by footwear choices, especially shoes that are narrow, pointed, or have a tight toe box
