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Phase I biotransformation seems to be enzymes that catalyzes oxidation, reduction or hydrolyze reactions, it usually converts substrates to more polar forms by introducing or unmasking a functional group (e.g., OH, NH2, or SH)
Huang C, Li J, Wu R, Li Y, Zhang C
Glutathione is the expert maintenance crew, moving around and fixing the small bits of wear and tear that happen every day, keeping the machinery running perfectly
LaRowe SD, Kalivas PW, Nicholas JS, et al
Iveson P, Lindup W, Parke D, Williams R (1971) The metabolism of carbenoxolone in the rat
Rizvi S, Raza S, Mahdi F
