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Hfe-KO chondrocytes revealed a favored expression of iron metabolism markers (such as Tf), indicating increased sensitivity to intracellular iron contents (Simo et al., 2019)

Patients typically present with gross hematuria and may experience colicky flank pain if sloughed tissue obstructs the ureter, though this patient's lack of pain, nausea, and urinary symptoms makes concurrent nephrolithiasis or infection unlikely

When restarting, the side effect experience during the second round of dose escalation is usually milder than the first

Vitamin D3 is a fat-soluble vitamin that can become toxic if levels are too high