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Masami Tanaka, Hiroshi Itoh Endocrinology and Metabolism.2016

Herbal therapies like American ginseng have shown some efficacy in trials (a Mayo Clinic-led RCT found 2000 mg daily of Wisconsin ginseng improved fatigue over placebo) [82], and a meta-analysis suggested ginseng can yield modest fatigue reduction [83]

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doi: 10.4239/wjd.v6.i2.217 41 MaieseKChongZZShangYC

NF-B, as a transcriptional regulator of DNA, plays a crucial role in the expression of more than 200 genes involved in immune and inflammatory responses 40,41

Pharmacodynamic Effects of Standard versus High Caffeine Doses in the Developing Brain of Neonatal Rats Exposed to Intermittent Hypoxia