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Keywords: oxidative damage, oxidative stress, reactive oxygen species, redox signaling, therapeutic targets Oxidative stress occurs when the reactive oxygen species (ROS) production overwhelms the ROS scavenging, which lead to genomic instability, epigenetic regulation, proteostasis imbalance, and lipid peroxidation, subsequently causing the occurrence and development of numerous diseases

It has been shown that many types of cells can trap NAC, hydrolyze it and change it into L-cysteine, which is then incorporated into the cycle of gamma glutamyl, stimulating glutathione synthesis [58]

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doi: 10.3389/fneur.2024.1366372 Received 08 January 2024 Accepted 12 April 2024 Published 06 May 2024 Volume 15 - 2024 Edited by Levent Ertugrul Inan, Health Science University Ankara SUAM, Trkiye Reviewed by Francesco De Logu, University of Florence, Italy Fu-Chi Yang, Tri-Service General Hospital, Taiwan Updates Copyright 2024 Chen, Yang, Tsai, Yang, Hsu, Chang and Yang