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Although the pathogenesis of these diseases is not fully understood, several neurological components have been already identified as responsible for the neuronal pathology such as increased protein aggregates, glial activation/inflammation, mitochondrial dysfunction, disbalance of neurotransmitters, autophagia or oxidative stress (Figure 1)

Drugs Targeting p53 Mutations with FDA Approval and in Clinical Trials

, Moynihan, E
doi:10.1016/s0029-7844(99)00610-9 [18] Gilfix BM

Olubodun JO, Ochs HR, Trten V, Klein A, von Moltke LL, Harmatz JS, et al

Allergic Cross-Reactivity of Cobalamins Since vitamin B12 can occur in various forms, the possibility of an allergic cross-reaction to different cobalamin variants seems likely, but based on the available literature data [80,81,82,83,84], this hypothesis cannot be unequivocally confirmed or ruled out
