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Footnotes Contributors AL and CW conceived the idea

Notably, the DHODH inhibitor brequinar was shown to suppress tumor growth in vivo, an effect partially attributed to enhanced ferroptotic vulnerability in GPX4-low tumors

If you or a loved one may have sustained a traumatic brain injury, keep reading to find out more about potential treatment options

Therefore, therapeutic strategies targeting astrocytic autophagy should be carefully tailored in a disease-stage- and context-dependent manner

After filtering to retain participants with information regarding pre-treatment and post-treatment BMI and genotype data passing quality control, we obtained 4,889 participants, of which 3,948 had complete data when incorporating covariates akin to those used in the GWAS

While 503B outsourcing facilities are subject to federal Current Good Manufacturing Practice (CGMP) regulations and must register with the FDA, traditional 503A compounders are exempt from CGMP regulations and are instead overseen primarily by state boards of pharmacy, potentially resulting in a patchwork of manufacturing regulation and oversight across states (Lisi, 2021