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doi: 10.1016/j.cct.2016.10.004

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Future medicinal chemistry efforts may yield next-generation compounds with enhanced properties, including improved tissue selectivity, modified pharmacokinetics, or additional mechanistic activities that complement NNMT inhibition

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The ratio of the two different types of melanin found in skin, black-brown colored eumelanin and yellow-red pheomelanin, determines the skin colour.[9] An increased proportion of pheomelanin is associated with lighter skin colour

The alkaline pH-adapted skin barrier is disrupted severely by SLS-induced irritation