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[PubMed] [Google Scholar] 73.Vidal-Alaball J., Butler C.C., Cannings-John R., Goringe A., Hood K., McCaddon A., McDowell I., Papaioannou A

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however, cytochrome P450 enzymes convert 59% of acetaminophen to N -acetyl-p-benzo-quinonimine (NAPQI), which causes hepatotoxicity by binding to cellular macromolecules