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Serious or permanent complications like blindness or kidney disease can arise if a diabetic is put through too many extreme sugar highs and lows

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It means the question is becoming more serious

Poor Dietary Intake Vegetarians, particularly those restricting milk and eggs, are at higher risk of B12 deficiency because there are limited plant-based food sources containing B12

Endocrine 84 , 4862 (2024)

These limitations do not invalidate preclinical findings but emphasize the need for human clinical trials with appropriate sample sizes, standardized protocols, and validated outcome measures before establishing clinical efficacy in human patients