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Due to the low water solubility of these two chemicals, they cannot penetrate cell membranes in aqueous conditions like biological fluids
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Moreover, thiamine is a potent inhibitor of advanced glycation end-product (AGE) formation by the non-enzymatic glycation of proteins by glucose [126]
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Ferecatu I, Goncalves S, Golinelli-Cohen MP, Clemancey M, Martelli A, Riquier S et al (2014) The diabetes drug target MitoNEET governs a novel trafficking pathway to rebuild an Fe-S cluster into cytosolic aconitase/iron regulatory protein 1
