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The underlying mechanism that accounts for the lifespan effect lies in the upregulated energy production and lysosome-related processes

elegans reveals longevity-associated targets of DAF-16/FoxO

The DEGs in Cluster 4 6 were all down-regulated in tcpDUO in comparison with wild type, and the DEGs in Cluster 4 all showed lower expression levels under HT in comparison with normal temperature (Supplementary Fig

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Future clinical studies should account for baseline choline status, microbiome profiles, genetic polymorphism in choline metabolic pathways, and organ-specific outcomes to define optimal strategies for leveraging the use of modulating choline availability and metabolism in personalized therapeutic interventions

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