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Exposure to environmental factors can be exogenous or endogenous in nature, including diet, chemical exposure, stress, and use of alcohol

This upregulation of glutamate transporters enhances glutamate uptake, thus facilitating cystine uptake and GSH synthesis, ultimately contributing to lung tumor development

These include IL-1 alpha, IL-2, IL-13, IFN-alpha, TNF-alpha, and IL-6 [38]

doi:10.1093/carcin/21.5.1051
Antioxidant enzyme nanocarrier formulations can be used to target endothelial cells to generate anti-inflammatory effects

When used in topical formulations, the most commonly reported issues are localised and mild, and may include: Skin irritation or redness at the site of application Contact dermatitis in individuals with sensitive skin or known peptide sensitivities Scalp itching or tingling , which may be transient The following precautions are advised: Avoid application to broken, inflamed, or irritated skin , and keep the product away from the eyes and mucous membranes
