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Exposure to environmental factors can be exogenous or endogenous in nature, including diet, chemical exposure, stress, and use of alcohol

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This upregulation of glutamate transporters enhances glutamate uptake, thus facilitating cystine uptake and GSH synthesis, ultimately contributing to lung tumor development

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These include IL-1 alpha, IL-2, IL-13, IFN-alpha, TNF-alpha, and IL-6 [38]

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doi:10.1093/carcin/21.5.1051

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Antioxidant enzyme nanocarrier formulations can be used to target endothelial cells to generate anti-inflammatory effects

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When used in topical formulations, the most commonly reported issues are localised and mild, and may include: Skin irritation or redness at the site of application Contact dermatitis in individuals with sensitive skin or known peptide sensitivities Scalp itching or tingling , which may be transient The following precautions are advised: Avoid application to broken, inflamed, or irritated skin , and keep the product away from the eyes and mucous membranes

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