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Key oncogenes, including mutant KRAS [40], PI3K [41], and MYC [31], drive this elevation by upregulating de novo nucleotide synthesis enzymes and enhancing glucose uptake to fuel the production of ATP, ribose, and amino acid precursors

Journal Pharmaceutics 630, 122420

28 Wapnir RA

MSU crystals have been shown to trigger IL-1 production and inflammatory cytokine release through C5a activation, highlighting the potential of complement antagonists in managing gout inflammation

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Improved survival for children and young adults with t-lineage acute lymphoblastic leukemia: results from the children's oncology group AALL0434 methotrexate randomization