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For some types of cancer distinct pathways can be more important than others, that could be in part attributed to the oncogenic addiction e.g
Sniderman et al., 2019)
Cholestanol is increased in cholestatic liver diseases due to decreased biliary secretion 17
These receptor interactions are of interest in experimental models evaluating how peptide signals influence cellular response and systemic regulation

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High-throughput small-molecule screening can now be coupled with AI/ML-driven chemical-structure modelling, similarity-based target prediction, and cross-species transcriptomics to markedly reduce off-target liabilities