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Melatonin signaling was shown to alleviate induced-cell apoptosis and improved the deleterious effects caused by insulin resistance (Figure 1) due to glucotoxicity and oxidative stress in human beta cells (Park et al., 2014) and reduction of p38 MAPK phosphorylation (Xu et al
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[DOI] [PMC free article] [PubMed] [Google Scholar] 58.Marciniak SJ, Chambers JE, Ron D.Pharmacological targeting of endoplasmic reticulum stress in disease
