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Some children show significant increases in communication in the first few months, and others take a bit longer

24 In addition, a number of powerful preformed inflammatory mediators are released, including cytokines (IL-4, IL-5, IL-6, IL-13, TNF- ) and chemokines (eg CXCL1 and CCL2), histamine, serglycin proteoglycans, and several mast cells-specific proteases (chymases, tryptases, and carboxypeptidase A

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