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Moreover, a Zn deficiency upregulates the mammalian ER stress, which indicates the induction of MT synthesis and enhanced stress response [65]
In contrast, the bulkier Y37 rAmy in rAmy-bound AMY 2 R prevents equivalent interactions of N35 rAmy with RAMP2, and instead the bulkier Y37 rAmy forms interactions with E101 RAMP2 and F111 RAMP2 stabilising the peptide at the CTR/RAMP ECD interface in the bypass conformation
L., Rosenfeld, M
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Bioessays, 40 (3)
