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Substantial contribution of extrinsic risk factors to cancer development

GLO I facilitates the conversion of MG with reduced glutathione to S-D-lactoylglutathione, preventing the non-enzymatic reaction of MG with proteins and DNA [140]

Synopsis In cancer cells dependent upon glucose for survival, glucose withdrawal activates a positive feedback loop involving reactive oxygen species (ROS), ROSmediated inhibition of tyrosine phosphatases, and tyrosine kinase signaling

10.1016/j.ejphar.2021.174039 Eur J Pharmacol

Bletilla striata polysaccharide promotes diabetic wound healing through inhibition of the NLRP3 inflammasome

10.1073/pnas.150084897 56 NorrgrdM