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It also acts as a signaling molecule that mediates macrophage activation, polarization, and NLRP3 inflammasome activation, through distinct signaling pathways [24], [25], [26]

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Coenzyme Q10 supplementation ameliorates inflammatory markers in patients with multiple sclerosis: a double blind, placebo, controlled randomized clinical trial

MMPs secreted by trophoblasts and cancer cells can shape the ECM, triggering its remodeling and facilitating invasion and the recruitment of immune cells

3.3 TRPM The TRPM family consists of eight members (TRPM1TRPM8), expressed in cells distributed in different tissues, such as the retina, kidney, pancreas, prostate, heart, intestine, and immune system (Huang et al., 2020