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Lectin-like, oxidized low-density lipoprotein receptor (LOX)-1, a scavenger receptor expressed in vascular ECs, smooth muscle cells and macrophages, is responsible for recognizing and internalizing ox-LDL
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Similarly, the Cu chaperone ATOX1 has also been found to serve as a modulator of angiogenesis, the depletion of Atox1 inhibit the migration of vascular smooth muscle cell that is stimulated by platelet-derived growth factor (PDGF), suggesting that ATOX1 likely plays a role in vascular remodeling and tumor angiogenesis
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