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Both Y179 4.63 A and F330 6.52 A substitutions cannot be activated by SR146131 as measured by the cAMP accumulation assay

The ratio of free GSH:GSSG pools increases when egtA is deleted, and drops again upon complementation (Supplementary Table S7, Supplementary Figure S6)

Bioavailability Bioavailability is defined as the fraction of unchanged drug reaching the systemic circulation following administration by any route ( Table 33 )

University of Maryland, Baltimore

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