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Rare anaphylactoid symptoms (facial pallor, blood pressure drop) may occur, so monitor the patient closely, and avoid nerves and blood vessels during IM injection

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As dopamine replacement treatment remains the most effective symptomatic pharmacotherapy for PD, herein we provide an overview of the current pharmacotherapies, summarize the clinical development status of novel dopaminergic agents, and highlight the challenge and opportunity of emerging preclinical dopaminergic approaches aimed at managing the features and progression of PD.
