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In the triple transgenic AD (3xTg-AD) mouse model, the development of AD pathologies, including A plaque, hyperphosphorylated tau, synaptic dysfunction, and microglial activation appears to be influenced by the gut microbiome
PloS Pathog (2014) 10(2):e1003940
This reaction produces NADH and acetaldehyde as immediate metabolic intermediates
So, pharmacological effect method is suitable for drugs with complex components and difficult to detect, and can more truly reflect the dynamic change process of drugs in vivo
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