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Mechanistically, the triple-agonist design is a deliberate departure from the GLP-1-monoagonist (liraglutide, semaglutide) and GIP/GLP-1-dual-agonist (tirzepatide) classes

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Although, macular xanthophylls in POS constitute about 1025% of the amount in the entire retina [30], the local concentration of macular xanthophylls in membranes of the rod outer segment is about 70% higher than in residual retina membranes [30]

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