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In addition, hyperglycemia exacerbates neural injury and impedes repair by disrupting microvascular integrity, altering immune cell function, disturbing ionic homeostasis within nerves, and inducing Schwann cells (SCs) apoptosis along with impaired production of neurotrophic factors
Among them are the decrease of AKT signaling through the inhibition of the RAPTOR/mTOR complex and the interaction of GNMT with the PTEN inhibitor, PREX2
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