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GHK-Cu suppressed the phosphorylation of p38 MAPK, JNK1/2 and NF-B p65 in LPS-induced ALI in mice The MAPK pathways have been demonstrated to participate in the activation of NF-kB in LPS-induced ALI

As such, most approaches to delivery have utilized gene therapy methods with the hope that the growth factor will be expressed in the correct location at a high enough concentration and for a long enough period to provide clinical relief

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doi: 10.1016/j.plipres.2022.101165, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 61.Chvez-Castillo M, Ortega A, Cudris-Torres L, Duran P, Rojas M, Manzano A, et al