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As mentioned above, mitochondria exhibit transmembrane potential across the inner membrane that is necessary for OXPHOS
Carbonic Anhydrases as Potential Targets Against Neurovascular Unit Dysfunction in Alzheimers Disease and Stroke

In oxidative stress conditions, multiple cysteine residues of KEAP1 are oxidized by ROS, causing structural changes followed by Zn release and complex dissociation [6,30]

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