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Primary cardiomyocyte and immortalized cell line models provide validated systems for mechanistic investigation, revealing concentration-dependent effects on focal adhesion assembly and actin polymerization dynamics

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So, inhibition of Src by PP2 reduces DPDPE-induced DOR phosphorylation of S363 and desensitization on the cAMP pathway but via an indirect mechanism

Similar assay protocols were used at both sites

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Searching for clinical trials This website provides information on individual clinical trials in the European Union and European Economic Area since its launch on 31 January 2022