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To view a copy of this licence, visit About this article Cite this article Su, Q.J., Ashenhurst, J.R., Xu, W

24 h following exposure to UVA/UVB irradiation and rutin/ascorbic acid treatment, cells were fixed with 10% trichloroacetic acid and stained with 0.4% sulforhodamine B in 10% acetic acid for 30 min

Through antioxidant synergy, it neutralizes reactive oxygen species produced by mitochondrial dysfunction and helps maintain cellular health during dopamine metabolism

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MSDs Musculoskeletal disorders ACNs Anthocyanins OP Osteoporosis RA Rheumatoid arthritis OA Osteoarthritis OS Osteosarcoma NSAIDs Nonsteroidal anti-inflammatory drugs pH Potential of hydrogen RANKL Receptor activator of nuclear factor-kappa ligand RANK Receptor activator of nuclear factor-kappa sRANKL Soluble RANKL OVX Ovariectomized BV/TV Ratio of bone volume to tissue volume Tb.Th Trabecular thickness Tb.N Trabecular number N.Nd/N.Tm Node to terminus ratio Tb.Sp Trabecular separation Ct.Th Cortical thickness SMI Structure model index ORAC Oxygen radical absorbance capacity CT Computed tomography NF-B Nuclear factor-kappa CTX-1 C-terminal telopeptide of type I collagen CAT Catalase TNF- Tumor necrosis factor-alpha P Phosphorus Ca Calcium Runx2 Runt-related transcription factor 2 OCN Osteocalcin OPN Osteopontin BSP Bone sialoprotein BMP Bone morphogenetic protein Smad Small mothers against decapentaplegic GSK-3 Glycogen synthase kinase-3 beta Sirt1 Sirtuin 1 ALP Alkaline phosphatase Osx Osterix Mepe Matrix extracellular phosphoglycoprotein Col11 Collagen type I alpha 1 chain OPG Osteoprotegerin t-BHP Tert-butyl hydroperoxide EFSA European Food Safety Authority ADI Acceptable daily intake NFATc1 Nuclear factor of activated T cells calcineurin-dependent 1 DC-STAMP Dendritic cell-specific transmembrane protein OC-STAMP Osteoclast stimulatory transmembrane protein CTR Calcitonin receptor CtsK Cathepsin K SOD Superoxide dismutase GPX Glutathione peroxidase ROS Reactive oxygen species BSO Butionine sulfoximine MDA Malondialdehyde IL-1 Interleukin-1 beta COX-2 Cyclooxygenase-2 iNOS Inducible nitric oxide synthase NO Nitric oxide AIA Adjuvant-induced arthritis CIA Collagen-induced arthritis MAPKs Mitogen-activated protein kinases ERK Extracellular signal-regulated kinase JNK c-Jun N-terminal kinase FLS Fibroblast-like synoviocytes IL-17A Interleukin-17A IL-17RA IL-17 receptor subunit A Cyr61 Cysteine-rich angiogenic inducer 61 IL-23 Interleukin-23 PI3K/Akt Phosphoinositide-3-kinase/protein kinase B GM-CSF Granulocyte-macrophage colony-stimulating factor TLR3 Toll-like receptor 3 IL-4 Interleukin-4 IL-6 Interleukin-6 IL-10 Interleukin-10 IL-18 Interleukin-18 IL-21 Interleukin-21 FoxP3 Forkhead box P3 ROR-T Retinoic acid-related orphan receptor gamma t MMPs Matrix metalloproteinases Treg Regulatory T NK Natural killer Sirt6 Sirtuin 6 Tfh T-follicular helper Tfr T follicular regulatory PGE2 Prostaglandin E2 STAT Signal transducer and activator of transcription Th17 T helper 17 HO Hydrogen peroxide ONOO Peroxynitrite T-AOC Total antioxidant capacity NOX4 NADPH oxidase 4 NLRP3 NLR family pyrin domain containing 3 IB Inhibitor of kappa B p-p65 Phosphorylated p65 PIAS3 Protein inhibitor of activated STAT-3 DMM Destabilization of the medial meniscus MIA Monosodium iodoacetate NKG2D Natural killer group 2D ECM Extracellular matrix AGEs Advanced glycation end products Nrf2 Nuclear factor (erythroid-derived 2)-like 2 c-PARP Cleaved poly (ADP-ribose) polymerase NIK NF-kB-inducing kinase IRAK1 IL-1 receptor-associated kinase-1 IKK IB kinase CII Type II collagen UA Uronic acid P21 Cyclin-dependent kinase inhibitor 1 s-GAG Sulfated glycosaminoglycan ADAMTS5 A disintegrin and metalloproteinase with thrombospondin motifs 5 HA Hyaluronic acid PPAR Peroxisome proliferator-activated receptor gamma Bax Bcl-2-associated X protein Bcl-xl B-cell lymphoma-extra large AMPK Adenosyl monophosphate-dependent protein kinase FOXO3a Forkhead box O3 Mv Malvidin Pg Pelargonidin Dp Delphinidin Pn Peonidin Pt Petunidin Cy Cyanidin EMT Epithelial-to-mesenchymal transition AEBR Anthocyanin-rich extract from black rice VME Vaccinium myrtillus extract MBE Maqui berry extract BBs Blackberries C3G Cyanidin-3-glucoside BC Blackcurrant AHs Anthocyanin-enriched polyphenols from Hibiscus syriacus L