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Age-related Eye Disease Study 2 (AREDS2), conducted for nearly 5 years in 3700 individuals with a mean age of 73 years, did not confirm a positive effect of supplementation with lutein (10 mg/day) or zeaxanthin (2 mg/day) (Chew et al
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These spectral differences have significant implications for photoprotection, skin disease modeling, and personalized therapeutic strategies

Nevertheless, several attempts have been made over the years to try to decrease the oxidative stress that plays a great part in its progression

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