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10.1007/s40620-020-00793-2 24 LabunskyyV

These findings, marked by elevated methylglyoxal (MG) production flux and steady-state concentrations, were linked to reduced GLO I activity, resembling conditions seen in hyperglycemia, a characteristic of diabetes [74]

Exercise mitigates risk factors associated with ageing-related cardiovascular diseases, promotes structural remodeling of the cardiovascular system, and enhances cardiac resilience, thereby facilitating cardiovascular health throughout the ageing process [115]

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J Endocrinol 202(3):431439 Harkavyi A, Abuirmeileh A, Lever R, Kingsbury AE, Biggs CS, Whitton PS (2008) Glucagon-like peptide 1 receptor stimulation reverses key deficits in distinct rodent models of Parkinsons disease

However, the actual mechanism of cellular death appears to be more closely related to the loss of available glutathione