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[DOI] [PMC free article] [PubMed] [Google Scholar] 76

Mutations in the genes encoding these proteins, as well as their abnormal expression, are associated with the pathogenesis of several diseases, including type 2 diabetes, insulin resistance, cancer, and neurodegenerative disorders

In the Phase 2 obesity trial published in the New England Journal of Medicine, the highest arm reached 24.2 percent average body weight loss at 48 weeks, and the curve had not flattened by the end

In this review, we describe a series of pruritogens and receptors involved in mediating itching in PN, including cytokines, neuropeptides, extracellular matrix proteins, vasculogenic substances, ion channels, and intracellular signaling pathways