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In addition, CRH exerts various influences on behavior, including cerebral activation and waking maintenance, through activation of CRH receptors, which are expressed in the basal prosencephalic areas, thalamus, hypothalamus, mesencephalus, brainstem, and pons (42)

This stability sets it apart from many other peptides used in laboratory research, making it a highly practical candidate for a wide range of experimental protocols

Because saliva clears formulations quickly, any extended surface residence would increase the peptide permeability

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