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Because the target range is the condition at which optimization of desired efficacy converges with acceptable toxicity risk, the time in target range (TTR) should be maximized

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Concanavalin A (ConA) induces acute liver injury, mimicking AIH, and serves as a key model for studying its mechanisms and treatments [208]
These materials provide both physical structure and biochemical signaling, guiding tissue growth along correct anatomical pathways while delivering regenerative signals directly to cells within the scaffold
doi: 10.1371/journal.ppat.1010617 125 ForteaJ.PeguerolesJ.AlcoleaD.BelbinO.Dols-IcardoO.Vaqu-AlczarL.et al
