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492 At a concentration of 1 nM, zinc can directly activate RyR2, which has a much higher affinity for zinc than Ca 2+ (about three-fold), providing an essential mechanistic explanation for the association between zinc dyshomeostasis and certain cardiomyopathies

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For information regarding the nutritional role of folate, please review the following article: Folate or folic acid is a water-soluble B vitamin that plays a fundamental role in a variety of functions in the human body, including cell division and homeostasis